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Publications

Groß VE, Gershkovich MM, Schöneberg T, Kaiser A, Prömel S (2022) NanoBRET in C. elegans illuminates functional receptor interactions in real time. BMC Mol Cell Biol. 23(1):8. Online ahead of print.

Matúš D, Post WB, Horn S, Schöneberg T, Prömel S (2022) Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function. Biochem Biophys Res Commun. 589:152-158. 

Liebscher I#, Cevheroğlu O, Hsiao CC, Maia AF, Schihada H, Scholz N, Soave M, Spiess K, Trajković K, Kosloff M, Prömel S# (2021) A Guide to Adhesion GPCR research. FEBS J. doi: 10.1111/febs.16258. Online ahead of print. # equal contribution and shared correspondence

Wittlake A, Prömel S#, Schöneberg T(2021) The Evolutionary History of Vertebrate Adhesion GPCRs and Its Implication on Their Classification. Int J Mol Sci. 22(21):11803. # equal contribution and shared correspondence

Kaczmarek I, Suchý T, Prömel S, Schöneberg T, Liebscher I, Thor D (2021) The relevance of adhesion G protein-coupled receptors in metabolic functions. Biol Chem. doi: 10.1515/hsz-2021-0146. Online ahead of print.

Gershkovich MM, Groß VE, Vu O, Schoeder TC, Meiler J, Prömel S, Kaiser A (2021) Structural perspective on ancient neuropeptide Y -like system reveals hallmark features for peptide recognition and receptor activation. J Mol Biol. 433(13):166992 

Gershkovich MM, Groß VE, Kaiser A, Prömel S (2019) Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system. Cell Commun Signal. 17(1):123. 

Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A (2019) The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 1456(1):5-25. 

Schöneberg T, Prömel S (2019) Latrophilins and Teneurins in invertebrates: no love for each other? Front. Neurosci.13:154. 

Heshof R, Visscher B, Prömel S, Hughes S (2019) Large-scale cultivation of Caenorhabditis elegans in a bioreactor using a labor-friendly fed-batch approach. Biotechniques. 67(1):33-39. 


Röthe J, Thor D, Winkler J, Knierim AB, Binder C, Huth S, Kraft R, Rothemund S, Schöneberg T, Prömel S (2019) Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release. Cell Reports 26(6):1573-1584

Matúš D, Prömel S (2018) G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity. J Dev Biol. 6(4)

Nazarko O, Kibrom A, Winkler J, Stoveken H, Leon K, Salzman G, Merdas K, Lu Y, Narkhede P, Tall G, Prömel S, Araç D (2018) A comprehensive mutagenesis screen of the adhesion GPCR Latrophilin-1/ADGRL1. iScience 3:264-278

Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T, Kittel RJ (2017) Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. Elife 8;6. pii: e28360

Demberg LM, Winkler J, Wilde C, Simon KU, Schön J, Rothemund S, Schöneberg T, Prömel S#, Liebscher I# (2017) Activation of adhesion GPCRs: agonist specificity of Stachel sequence-derived peptides. J Biol Chem. 292(11):4383-4394 # equal contribution and shared correspondence

Merkwitz C, Blaschuk O, Winkler J, Schulz A, Prömel S, Ricken AM (2017) Advantages and limitations of salmon-Gal/tetrazolium salt histochemistry for the detection of LacZ reporter gene activity in murine epithelial tissue. J Histochem Cytochem. 65(4):197-206

Strutt D, Schnabel R, Fiedler F, Prömel S (2016) Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration. In: Langenhan, Schöneberg (Eds.) Adhesion G Protein-coupled Receptors, Handbook of Experimental Pharmacology Vol. 234, Springer International Publishing Switzerland

Prömel S#, Fiedler F, Binder C, Schöneberg T, Thor D# (2016) Deciphering and modulating G protein signalling in C. elegans using the DREADD technology. Sci Rep. 6:28901 # equal contribution and shared correspondence

Winkler J, Prömel S (2016) The adhesion GPCR latrophilin – a novel signaling cascade in oriented cell division and anterior-posterior polarity. Worm 5(2) e1170274

Merkwitz C, Blaschuk O, Eplinius F, Winkler J, Prömel S, Schulz A, Ricken A (2015) A simple method for inducing estrous cycle stage-specific morphological changes in the vaginal epithelium of immature female mice. Lab Anim. 0023677215617387

Müller A, Winkler J, Fiedler F, Sastradihardja T, Binder C, Schnabel R, Kungel J, Rothemund S, Hennig C, Schöneberg T, Prömel S (2015) Oriented cell division in the C. elegans embryo Is coordinated by G-protein signaling dependent on the Adhesion GPCR LAT-1. PLoS Genet. 11(10):e1005624.

Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (2015) International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 67(2):338-67.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X (2014) New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci.1333:43-64.

Prömel S, Langenhan T, Araç D (2013) Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins. Trends Pharmacol Sci. 34(8):470-8.

Liebscher I, Schöneberg T, Prömel S (2013) Progress in demystification of adhesion GPCR. Biol Chem 394(8): 937-950.

Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T (2012) Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 1276:1-25.

Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP, Langenhan T (2012) The GPS motif is a molecular switch for bimodal activities of Adhesion-class G protein-coupled receptors. Cell Reports 2(2): 321-331.

Prömel S#, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Grosse J, Schöneberg T, Russ AP, Langenhan T# (2012) Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn. 241(10):1591-1602.  #shared correspondence

Gregory AP, Dendrou CA, Attfield KE, Haghikia A, Xifara DK, Butter F, Poschmann G, Kaur G, Lambert L, Leach OA, Prömel S, Punwani D, Felce JH, Davis SJ, Gold R, Nielsen FC, Siegel RM, Mann M, Bell JI, McVean G, Fugger L (2012) TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 488(7412):508-11.

Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Davies B, Aparicio SA, Grosse J, Russ AP (2010) The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One 18;5(11):e14047

Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP (2009) Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Dev Cell 17(4):494-504.

Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID (2008) Solution Structure and Sugar-Binding Mechanism of Mouse Latrophilin-1 RBL: a 7TM Receptor-Attached Lectin-Like Domain. Structure 16(6):944-953.

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